Jeptha P. Curtis, MD Assistant Professor of Medicine

B.A., Yale University 1993; M.D., Columbia College of Physicians and Surgeons 1997; Internship and Residency in Internal Medince, Duke University Medical Center 2000; Post-Doctoral Fellow in Cardiovascular Disease, Yale University, 2004; Joined Yale Faculty 2004.

Outcomes Research in Interventional Cardiology:

My research focuses on the interface of interventional cardiology and health services research. Advances in technology have greatly expanded the diagnostic and therapeutic options available to interventional cardiologists. Currently, however, systematic efforts to monitor the diffusion of these novel technologies, assess the safety and effectiveness of these therapies outside the setting of clinical trials, and ensure that new technologies are being applied in the most efficient and efficacious manner have fallen behind the pace of discovery. Critically examining the practice of interventional cardiology is a key step to improving the quality of care delivered to patients with coronary artery disease.



Current efforts are aimed at examining factors influencing the adoption of drug-eluting stents into routine practice, developing methods to determine procedural appropriateness, and evaluating expectations of patients undergoing percutaneous coronary interventions.





Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. Beta blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 2002;288:351-357.



Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM, Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 2003, 289:871-878



Curtis JP, Sokol SI, Wang Y, Rathore SS, Jadbabaie F, Portnay EL, Ko DT, Marshalko SM, Radford M, Krumholz HM. The association of LVEF and mortality in stable outpatients with heart failure. J Am Coll Cardiol 2003;42:736-42.



Curtis JP, Portnay EL, Wang Y, Masoudi FA, Havranek E, Krumholz HM. Aspirin, ibuprofen and mortality after AMI. BMJ 2003;327:1322-1323.



Curtis JP, Rathore SS, Wang Y, Krumholz HM. The association of 6-minute walk distance and outcomes in stable outpatients with heart failure. Journal of Cardiac Failure 2004;10:9-14



Ko DT, Herbert P, Coffey C, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM. A quantitative overview of adverse effects of Beta-blocker therapy in patients with heart failure. Arch Intern Med 2004;164:1389-94



Vitagliano G, Curtis JP, Concato J, Feinstein AR, Radford MJ, Krumholz HM. Association of functional status with use and effectiveness of B-Blocker prophylaxis in elderly survivors of acute myocardial infarction. J Am Ger Soc 2004; 52:495-501



Curtis JP, Alexander J, Huang Y, Wallentin L, Verheugt F, Armstrong P, Krumholz HM, Van de Werf F, Granger C. Efficacy and safety of two unfractionated heparin dosing strategies with tenecteplase in acute myocardial infarction: Results from ASSENT-2 and ASSENT-3. Am J Cardiol 2004;94:279-83



Sokol SI, Portnay EL, Curtis JP, Nelson MA, Hebert PR, Setaro JF, Foody JM. Modulation of the Renin Angiotensin Aldosterone system for the secondary prevention stroke: therapeutic mechanisms and contemporary trial evidence. Neurology 2004;63:208-13



Masoudi FM, Rathore SS, Wang Y, Foody JM, Havranek E, Curtis JP, Krumholz HM. National patterns of use of angiotensin-converting enzyme inhibitors in elderly patients admitted with heart failure. Circulation 2004;110:724-31



Curtis JP, Ko DT, Wang Y, Khamiees RM, Wackers FJ, Foody JM. The prognostic importance of vasodilator SPECT myocardial perfusion imaging in octogenarians. Journal of the American Society of Geriatric Cardiology 2004;13:239-45



Curtis JP, Krumholz HM. Keeping the patient in view: Defining the appropriateness of percutaneous coronary interventions. Circulation 2004;110:3744-5



Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Portnay EL, Sokol SI, Kosiborod M, Bader F, Krumholz HM. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med. 2005;165:55-61



Magid DJ. Wang Y. Herrin J. McNamara RL. Bradley EH. Curtis JP. Pollack CV Jr. French WJ. Blaney ME. Krumholz HM. Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction. JAMA. 2005;294(7):803-12



Heitner JF. Curtis JP. Haq SA. Corey GR. Newby LK. Jollis JG. The significance of elevated troponin T in patients with nondialysis-dependent renal insufficiency: a validation with coronary angiography. Clinical Cardiology. 28(7):333-6



Portnay EL, Foody JM, Rathore SS, Wang Y, Masoudi FA, Curtis JP, Krumholz HM. Prior Aspirin Use and Outcomes in Elderly Patients Hospitalized With Acute Myocardial Infarction. J Am Coll Cardiol. 2005;46:967-74



Kosiborod M, Curtis JP, Smith GL, Masoudi FM, Havranek E, Krumholz HM, Anemia in elderly patients admitted with heart failure. Arch Intern Med./ 2005;165:2237-2244
Kim N, Gross CP, Curtis JP, Stettin GD, Wogen S, Choe N, Krumholz HM. The impact of clinical trials on the use of hormone replacement therapy: a population-based study. J Gen Intern Med 2005;20:1026-1031.

McNamara RL, Herrin J, Bradley EH, Portnay EL, Curtis JP, Wang Y-F, Magid DJ, Blaney M, Krumholz HM for the NRMI Investigators. Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999-2002. J Am Coll Cardiol 2006;47:45-51.

Curtis JP, Portnay EL, Wang Y-F, McNamara RL, Herrin J, Bradley EH, Magid DJ, Blaney ME, Canto JG, Krumholz HM. The pre-hospital electrocardiogram and time to reperfusion in patients with acute myocardial infarction, 2000-2002. Findings from the National Registry of Myocardial Infarction-4. J Am Coll Cardiol 2006;47:1544-1552.

Rathore SS, Masoudi FA, Wang Y-F, Curtis JP, Foody JM, Havrenek EP, Krumholz HM. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: findings from the National Heart Failure Project. Am Heart J 2006;152:371-8.

McNamara RM, Wang Y-F, Herrin J, Curtis JP, Bradley EH, Magid DJ, Peterson ED, Blaney M, Frederick PD, Krumholz HM. Effect of door-to-balloon time on mortality in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol 2006;47:2180-6.

Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for reducing the door-to-balloon time in acute myocardial infarction. New Engl J Med 2006;355:2308-20.

Curtis JP, Cohen DJ, Jones P, Bach RG, Spertus JA, Krumholz HM. Impact of an FDA Public Health Notification on Clinical Practice: Adoption of Drug Eluting Stents in Patients with Acute Coronary Syndromes. Am J Cardiology 2007;99:1227-9

Nallamothu BK. Wang Y. Bradley EH. Ho KK. Curtis JP. Rumsfeld JS. Masoudi FA. Krumholz HM. Comparing hospital performance in door-to-balloon time between the Hospital Quality Alliance and the National Cardiovascular Data Registry. J Am Coll Cardiol 2007;50:1517-9.

Bradley EH. Nallamothu BK. Curtis JP. Webster TR. Magid DJ. Granger CB. Moscucci M. Krumholz HM. Summary of evidence regarding hospital strategies to reduce door-to-balloon times for patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Criti Paths Cardiol 2007;6:91-7.

McNamara RL. Herrin J. Wang Y. Curtis JP. Bradley EH. Magid DJ. Rathore SS. Nallamothu BK. Peterson ED. Blaney ME. Frederick P. Krumholz HM. Impact of delay in door-to-needle time on mortality in patients with ST-segment elevation myocardial infarction. Am J Cardiol 2007;100:1227-32.

Ko DT. Wang Y. Alter DA. Curtis JP. Rathore SS. Stukel TA. Masoudi FA. Ross JS. Foody JM. Krumholz HM. Regional variation in cardiac catheterization appropriateness and baseline risk after acute myocardial infarctionJ Am Coll Cardiol 2008;51:716-23.

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Last modified:Wednesday, 09-Apr-2008 12:54:48 EDT (PL).