Stuart D. Katz, M.D. Associate Professor of Medicine Dept. of Internal Medicine (Cardiology) Heart Failure Clinic

B.S., Yale University 1979; M.D. SUNY Downstate Medical Center, Brooklyn NY, 1983; Residency in Internal Medicine, Francis Scott Key Medical Center, Johns Hopkins Medical Institutions, Baltimore, MD. 1984-1986; Cardiology Fellowship, Albert Einstein College of Medicine, Bronx, N.Y, 1986-89; joined Yale Faculty, 2001.

Studies in Heart Failure

The Clinical Vascular Physiology Laboratory in the Yale Heart Failure Center investigates the role of blood vessel physiology in the pathogenesis of human disease. Physiological measures of conduit and resistance blood vessel structure and function are applied in human subjects to delineate mechanisms of disease, provide a detailed characterization of vascular phenotype, and determine the role of blood vessels in response to treatment and disease progression. Heart failure has been the long-standing major interest in the laboratory, but recent investigations have also included studies on the potential role of iron-mediated oxidative stress on blood vessel function and progression of atherosclerosis and genetic determinants of vascular function. Our Laboratory has a strong commitment to training of young investigators.


Zheng H, Cable R, Spencer B, Votto N, Katz SD: Endothelial Function in Voluntary Blood Donors. Arteriosclerosis, Thrombosis, and Vascular Biology 2005;25:1577-1583. .

Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, Yasskiy A: Vascular endothelial function and survival in patients with chronic heart failure. Circulation 2005; 111:310-314. .

Hrynewicz K, Dimayuga C, Hudaihed A, Androne AS, Zheng H, Katz SD: Comparative effects of angiotensin converting-enzyme inhibition and phosphodiesterase type 5 inhibition on vascular endothelial function in patients with chronic heart failure: A randomized, double-blind, placebo-controlled trial. Clin Sci (Lond) 2005; 108(4): 331-8. .

Upadya S, Sedrakyan A, Saldarriaga C, Nystrom, K, Bozzo J, Lee FA, Katz SD: Comparative costs of home positive inotropic infusion vs. in-hospital care in patients awaiting cardiac transplantation. J Cardiac Failure 2004;10:384-389. .

Androne AS, Hudaihed A, Hryniewicz K, Mancini D, LaManca J, Katz SD: Unrecognized hypervolemia in chronic heart failure: Relation to clinical status, hemodynamics, and patient outcomes. Am J Cardiol 2004;93:1254-1259. .

Upadya S, Lee FA, Saldarriaga C, Verma S, Sedrakyan A, Nystrom K, Katz SD: Home continuous positive inotropic infusion as a bridge to cardiac transplantation in patients with end-stage heart failure. J Heart Lung Transplant 2004; 23:466-472. .

Hryniewicz K, Androne AS, Hudaihed A, Katz SD: Partial reversal of cachexia by beta-adrenergic receptor blocker therapy in patients with chronic heart failure. J Card Failure 2003; 9:464-468. .

Hyrniewicz K, Androne AS, Hudaihed A, Katz SD: Comparative effects of carvedilol and metoprolol on regional vascular responses to adrenergic stimuli in normal subjects and patients with chronic heart failure. Circulation 2003; 108:971-976. .

Katz SD, Krum H. Acetylcholine-mediated vasodilation in the forearm circulation of with heart failure: indirect evidence for role of endothelium-derived hyperpolarizing factor. Am J Cardiol 2001;87:1089-1092.

Katz SD, Balidemaj K, Homma S, Wu H, Wang J, Maybaum S: Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol 2000, 36:845-851.

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