Yi-Hwa Liu, Ph.D. Associate Professor of Cardiovascular Medicine Department of Internal Medicine and Diagnostic Imaging

B.S., Biomedical Engineering, Chung-Yuan University, Chung-Li, Taiwan, 1981; M.S., Electrical and Computer Engineering, University of Missouri, Columbia, Missouri, 1987; Ph.D., Electrical and Computer Engineering, Rensselaer Polytechnic Institute, Troy, New York, 1991; Post-Doctoral Fellow, Georgetown University School of Medicine, Washington, DC, 1991-1993; Post-Doctoral Associate, Cardiovascular Medicine, Yale University School of Medicine, 1993-1995; Associate Research Scientist, Cardiovascular Medicine, Yale University School of Medicine, 1995-1998; Assistant Professor, Cardiovascular Medicine, Yale University School of Medicine, 1998-2004.

Research in Nuclear Cardiac Imaging

My primary research has focused on new developments of automatic quantification and iterative image restoration and reconstruction methods for nuclear cardiac tomographic imaging. The new developments promise to improve image resolution and enhance detection of abnormalities of myocardial perfusion and left ventricular function. My latest work is focused on novel small animal imaging techniques using hybrid coded aperture and parallel-hole collimation, and developments of new “hot-spot” quantification methods for targeted molecular imaging using innovative stochastic methodology incorporated with a dual-isotope SPECT imaging technique. I am also involved in developments of remote reading strategy for nuclear cardiac studies using secured World-Wide-Web technology.


Shi CQ, Young LH, Daher E, Dibella EVR, Dione DP, Liu YH, Heller EN, Zoghbi S, Arrighi JA, Wackers FJTh, Soufer R, Sinusas, AJ. Correlation of myocardial Para-[123I]Iodophenyl-pentadecanoic acid (P-[123I]PPA) retention with [18F]Flurodeoxyglucose accumulation during experimental low flow ischemia. J Nucl Med 2002;43:421-431.

Liu YH, Lam PT, Sinusas AJ, Wackers FJTh. Differential effect of 1800 and 3600 acquisition orbits on the accuracy of Tc-99m SPECT: quantitative evaluation in phantoms. J Nucl Med 2002;43:1115-1124.

Samady H, Liu YH, Choi CJ, Ragosta M, Pfau SE, Cleman MW, Powers R, Kramer CM, Wackers FJTh, Beller GA, Watson DD. Electromechanical mapping for detecting myocardial viability and ischemia in patients with severe ischemic cardiomyopathy. Am J Cardiol 2003;91:807-811.

Liu YH, Lam PT, Sinusas AJ, Wackers FJTh. Letter to the editor. Reply to comments on “Effect of Acquisition Orbit on SPECT in Phantoms” by D. Kirch, et al. and on “Cardiac SPECT: 360° Circular Acquisition May Resolve Defects of 180°Data” by W-J Shih, et al. J Nucl Med 2003;44:995-996.

Navare SM, Wackers FJTh, Liu YH. Comparison of 16-frame and 8-frame gated SPECT imaging for estimation of left ventricular volumes and ejection fraction. Eur J Nucl Med, 2003;30:1330-1337.

Liu YH, Khaimov D, Sinusas AJ, Wackers FJTh. Gated SPECT quantification for myocardial thickness, left ventricular volumes and ejection fraction: methodology and phantom validation. Proceeding of IEEE Nuclear Science and Medical Imaging 2003; Paper # M11-299 (5 pages).

Liu YH, Sinusas AJ, Khaimov D, Gebuza BI, Wackers FJTh. New hybrid count and geometry-based method for quantification of left ventricular volumes and ejection fraction from ECG-gated SPECT: methodology and validation. J Nucl Cardiol 2005;12:55:65.

Liu YH, Khaimov D. A Geometry and count-based method for gated SPECT quantification of myocardial thickness, left ventricular volume and ejection fraction. IEEE Trans Nucl Sci 2005; 52:159-165.

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Last modified: Tuesday, 31-May-2005 13:54:57 EDT (PL).