What is the purpose of this trial?
Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.
Ages: 35 years and older
National Institute of Neurological Disorders and Stroke
Dates: 07/20/2015 - 12/31/2020
Last Updated: 02/22/2018
Study HIC#: 1501015248