Prevalence of Carbohydrate Intolerance in Lean and Obese Children

Trial Purpose and Description

The purpose of this study is to determine the prevalence of impaired glucose (carbohydrate) tolerance in lean children with a family history of diabetes and in overweight/obese children with or without a family history of diabetes mellitus. A secondary purpose of this research project is to study lean children and adolescents with a family history of diabetes and overweight/obese children with or without a family history of diabetes and their predisposition to atherosclerosis and adverse cardiovascular outcomes. Specifically, the hypothesis is that children with metabolic risk factors will have altered endothelial function. A third purpose of this study is to understand the molecular physiology of obesity and type 2 diabetes (T2DM) in lean children with a family history of diabetes and in overweight/obese children with or without a family history of diabetes mellitus using candidate gene and positional cloning approaches. The goal is to identify genes in which mutation and/or allelic variation convey susceptibility to obesity, T2DM and/or related sub-phenotypes in youth. The identification of such genes should enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment. Specifically, we plan to: 1. Explore the genetic bases of T2DM-associated quantitative traits, with special regard to insulin sensitivity and insulin secretion. 2. Confirm (or disprove) that genes associated with T2DM-associated quantitative traits are true diabetogenes.

Ages: 8 - 18 years

Gender: Both


Eligibility Criteria

Inclusion Criteria:

  • Obesity: BM +/- 95% for age general good health


National Institute of Child Health and Human Development

Dates: 09/24/1999 - 09/23/2019

Last Updated: 11/06/2015

Study HIC#: 9909011190

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Investigators

Sub-Investigators