Transfusion Requirements in Cardiac Surgery III (TRICS-III)

Trial Purpose and Description

The principal question to be addressed is whether a restrictive transfusion threshold is non-inferior to a higher threshold as measured by a composite outcome of mortality and serious morbidity (cardiac, renal, and neurological events).

Ages: 18 years and older

Gender: Both


Eligibility Criteria

Inclusion Criteria:

Age 18 or older
Planned cardiac surgery using cardiopulmonary bypass
Informed consent obtained
Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more



Exclusion Criteria:
Patients who are unable to receive or who refuse blood products
Patients who are involved in the autologous pre-donation program
Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential.)
Patients who are unable to receive or who refuse blood products


Canadian Institutes of Health Research (CIHR)

Dates: 01/13/2016 - 03/31/2018

Last Updated: 12/07/2016

Study HIC#: 1503015523

Get Involved

For more information about this study, contact:
Karen B Stavris
203-737-5037
karen.stavris@yale.edu

If you would prefer to contact a member of the Help us Discover team about this trial and other similar trials, please email helpusdiscover@yale.edu or call 1-877-978-8348.

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